师资队伍

Teaching Staff

郝志敏

职称:

教授

博士生导师/硕士生导师

研究领域:

病原真菌与寄主互作机制,作物真菌病害绿色防控技术

招生方向:

微生物学,生物与医药

联系方式:

hzm_0322@163.com

学习经历

1997-2001  河北大学,学士

2002-2005  河北大学,硕士

2005-2008  河北农业大学,博士

工作经历

2008-2011   河北农业大学生命科学学院讲师

2011-2018   河北农业大学生命科学学院,副教授

2018         河北农业大学生命科学学院,教授

2014-2015   美国伊利诺伊大学香槟分校作物科学系,访问学者

荣誉称号及社会兼职

河北省微生物学会副理事长、农业微生物专业委员会主任,2023-2028;

教学工作

本科生课程:

1. 专业基础课《基础微生物学》、《药学微生物学》、《微生物学与免疫学》

2. 专业选修课《微生物工程》

研究生课程:

《生物学专业英语》

主要研究方向及领域

微生物资源与利用

寄主-病原物互作分子机制

主持课题

1.玉米大斑病菌效应蛋白StCFEM12靶向ZmFd1促进寄主感病的分子机制. 国家自然科学基金(32472501), 2025-2028, 主持

2.玉米大斑病生防菌筛选及其互作机制研究. 国家重点研发计划子课题(2023YFD1401503), 2023-2027, 主持

3. 玉米大斑病菌StLCB1和StLCB2基因调控附着胞发育的分子机制及其dsRNA对病菌的抑制作用. 中央引导地方科技发展资金项目(246Z6505G), 2024-2027, 主持

4. 内生微生物组生态调控玉米镰孢菌病害的机制与应用. 河北省重点研发计划(20326503D), 2020-2022, 主持

5. 玉米大斑病菌转录调控因子StFlo8调控极性生长的分子机制. 河北省自然科学基金面上项目(C2020204172), 2020-2022, 主持

6. 夏玉米病害无害化防控及化肥农药协同增效模式创新. 国家重点研发计划子课题(2018YFD0200607-02), 2018-2020, 主持

7. 钙/钙调素依赖性蛋白激酶(CaMK)基因家族调控玉米大斑病菌致病性的功能解析. 河北省自然科学基金(C2016204160, 2016-2018, 主持

8. StPKA-c调控玉米大斑病菌侵染能力的分子机制. 国家自然科学基金(31301616), 2014-2016, 主持

出版教材著作

主编,冀中南夏玉米化肥农药减施增效技术. 河北大学出版社,2024.

代表性学术成果

研究论文(*通讯作者):

1.Liu Yuwei, Liu Jiayue, Sun Mingqing, Mao Yanan, Feng Shang, Shen Shen, Liu Tingting, Cao Zhiyan, Li Zhiyong, Hao Zhimin*, Dong Jingao. The genome sequencing and comparative genomics analysis of Rhizoctonia solani reveals a novel effector family owning a uinque domain in Basidiomycetes. International Journal of Biological Macromolecules, 2024, 278: 134328.

2.Li Pan, Shen Shen, Jia Jingzhe, Sun Hehe, Zhu Hang, Wei Ning, Yu Bo, Aamir Sohail, Wu Di, Zeng Fanli, Hao Zhimin*, Dong Jingao. The catalytic subunit of type 2A protein phosphatase negatively regulates conidiation and melanin biosynthesis in Setosphaeria turcica. International Journal of Biological Macromolecules, 2024, 266: 131149.

3.Li Pan, Sun Hehe, Han Xinpeng, Long Feng, Shen Shen, Li Zhiyong, Hao Zhimin*, Dong Jingao. The septin gene StSep4 contributes to the pathogenicity of Setosphaeria turcica by regulating the morphology, cell wall integrity and pathogenic factor biosynthesis. Journal of Agricultural and Food Chemistry, 2023, 71(49): 19568-19580.

4.Li Pan, Zhu Hang, Wang Chengze, Shen Shen, Zeng Fanli, Sohail Aamir, Wang Yanhui, Hao Zhimin*, Dong Jingao. StRAB4 gene is required for filamentous growth, conidial development, and pathogenicity in Setosphaeria turcica. Frontiers in Microbiology, 2024, 14: 1302081.

5.Liu Jiayue, Feng Shang, Liu Tingting, Yanan Mao, Shen Shen, Liu Yuwei, Hao Zhimin*, Li Zhiyong. Molecular characterization revealed the role of thaumatin-like proteins of Rhizoctonia solani AG4-JY in inducing maize disease resistance. Frontiers in Microbiology, 2024, 15: 1377726.

6.Liu Yuwei, Jia Lixia, Zhou Cheng, Mao Yanan, Shen Shen, Hao Zhimin*, Li Zhiyong. Genome resource of Rhizoctonia solani anastomosis group 4 strain AG4-JY, a pathomycete of sheath blight of foxtail millet. Plant Disease, 2023,107(3): 926-928.

7.Han Shipeng, Sun Donghui, Zhou Cheng, Wang Qing, Chen Jie, He Yunzhuan, Hao Zhimin*. First report of Botryosphaeria dothidea causing stem blight of Dioscorea oppositifolia in China. Plant Disease, 2023, 107(7): 2232.

8.Hao Zhimin, Liu Yuwei, Liu Jiayue, Zhou Cheng, Shen Shen, Dong Jingao, LI Zhiyong. First report of Rhizoctonia solani AG-4 HG-III causing sheath blight on foxtail millet in China. Plant Disease, 2023,107(7): 2223.

9.Li Pan, Sun Hehe, Dong Jingao, Hao Zhimin*. Protein kinase C is required for the pathogenicity of Setosphaeria turcica on maize. Journal of Plant Pathology, 2023, 105(3): 683-693.

10.Liu Yuwei, Shen Shen, Hao Zhimin*, Wang Qing, Zhang Yumei, Zhao Yulan, Tong Yameng, Zeng Fanli, Dong Jingao. Protein kinase A participates in hyphal and appressorial development by targeting Efg1-mediated transcription of a Rab GTPase in Setosphaeria turcica. Molecular Plant Pathology, 2022, 23:1608-1619.

11.Han Shipeng, Wang Qing, Zhang Shuo, Jin Xi, Hao Zhimin*, He Yunzhuan. First report of Alternaria tenuissima causing brown spot disease on Angelica dahurica in China. Plant Disease, 2022,106(1): 332.

12.Wang Jianxia, Long Feng, Zhu Hang, Zhang Yan, Wu Jianying, Shen Shen, Dong Jingao, Hao Zhimin*. Bioinformatic analysis and functional characterization of CFEM proteins in Setosphaeria turcica. Journal of Integrative Agriculture, 2021, 20(9): 2438-2449.

13.Zeng Fanli, Meng Yanan, Hao Zhimin(共一), Li Pan, Shen Shen, Cao Zhiyan, Dong Jingao. Setosphaeria turcica ATR turns off appressorium-mediated maize infection and triggers melanin-involved self protection in response to genotoxic stress. Molecular Plant Pathology, 2020, 21: 401-414.

14.Li Pan, Liu Xueqin, Hao Zhimin*, Jia Yanrong, Zhao Xiangdong, Xie Debao, Dong Jingao, Zeng Fanli. Dual repressive function by Cip1, a budding yeast analog of p21, in cell-cycle START regulation. Frontiers in Microbiology, 2020, 11: 1623.

15.Zhang Hong, Huang Xinzheng, Jing Weixia, Liu Danfeng, Khalid Hussain Dhiloo, Hao Zhimin*, Zhang Yongjun. Two farnesyl pyrophosphate synthases, GhFPS1-2, in Gossypium hirsutum are involved in the biosynthesis of farnesol to attract parasitoid wasps. Journal of Integrative Agriculture, 2020, 19(9): 2274-2285.

16.Liang Hailong, Wang Qing, Shen Shen, Jia Yanrong, Li Pan, Zeng Fanli, Hao Zhimin*, Dong Jingao. Yeast surface displayed xylanase is an efficient strategy to induce corn defence response. Biotechnology & Biotechnological Equipment, 2020, 34(1): 665-672.

17.王程泽, 张燕, 付伟, 贾京哲, 董金皋, 申珅, 郝志敏*. 玉米ACO基因家族生物信息学分析及表达模式分析. 中国农业科学, 2024, 57(7): 1308-1318.

18.孙贺贺, 王程泽, 贾京哲, 申珅, 郝志敏*, 董金皋. 玉米大斑病菌转录调节因子StFlo8互作蛋白的筛选与鉴定. 农业生物技术学报, 2024, 32(6): 1385-1392.

19.钱欣雨, 王会敏, 候美玲, 申珅, 郝志敏*, 董金皋. 玉米内生菌YY1菌株抗菌蛋白的稳定性和活性组分分析. 植物保护学报, 2023, 50(3): 725-732.

20.武建颖, 张燕, 孙贺贺, 赵玉兰, 董金皋, 申珅. 郝志敏*. 玉米大斑病菌蛋白激酶 A 催化亚基 StPKA-C1/C2的表达与互作蛋白筛选. 农业生物技术学报, 2022, 30(10): 1976-1986.

21.李天聪, 朱行, 魏宁, 龙凤, 武建颖, 张燕, 申珅, 郝志敏*, 董金皋. 玉米大斑病菌SC35同源基因表达规律与互作分析. 中国农业科学, 2021, 54(4): 733-743.

22.刘彦策, 王会敏, 钱欣雨, 李慧颖, 申珅, 郝志敏*, 董金皋. 玉米内生菌L10的分离、鉴定及拮抗活性分析. 植物保护学报, 2021, 48(3): 630-637.

23.王建霞, 王擎, 赵玉兰, 李天聪, 龙凤, 朱行, 申珅, 郝志敏*. 玉米大斑病菌GATA转录因子氮源响应表达模式分析. 农业生物技术学报, 2020, 28(7): 1297-1305.

24.龙凤, 王擎, 朱行, 王建霞, 申珅, 刘宁, 郝志敏*, 董金皋. 玉米大斑病菌Septin基因家族的鉴定与表达模式分析. 中国农业科学, 2020, 53(24): 5017-5026.

发明专利:

1. 郝志敏,孙东辉,申珅,董金皋,曾凡力. 一株侵占木霉及其微生物菌剂、制备方法和应用. 发明专利, ZL202211083689.X2023-08-01

2. 钱欣雨,田赐,张利辉,郝志敏,董金皋. 一种死谷芽孢杆菌及其应用,发明专利,ZL202110931495.X2022-11-26

3. 郝志敏,曾凡力,胡玉笑,贾艳荣,赵相东,董金皋,申珅. 一种基因无痕编辑载体及其在生物体基因编辑中的应用. 发明专利,ZL201810524747.52021-7-13

4. 郝志敏,王会敏,董金皋,梁海龙,申珅,曾凡力. 一种多粘类芽孢杆菌、应用及微生物菌剂、粉剂和颗粒剂. 发明专利,ZL201811452399.12021-06-08



 

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